Ten years of regional coalition collaboration resulted in idea sharing and some program sharing. The sudden challenges of youth vaping, COVID-19, and potential non-medical marijuana legalization, provided new opportunities for collaboration between coalitions and new sectors and partners. This presentation will focus on how 20 coalitions from demographically diverse communities were able to increase youth involvement, increase parent involvement, and increase collaboration with community groups such as the Lung Association, the Heart Association, local Health Department, and government as well as with schools, mental and physical health care providers, and other youth serving agencies. The results were decreases in 8th, 10th, and 12th grade rates of 30-day alcohol use, marijuana use and vaping.