Overdoses are poorly understood and tragic and have become increasingly common over the past 50 years. Prevention works and is 100% effective in those for whom it works. It is inexpensive, safe, non-addicting and effective at saving lives. We face a complex and ever-evolving substance misuse and overdoses crisis. Treatments for substance use disorder, such as medication assisted treatment, are limited by poor adherence to treatment recommendations and relapse. This session explores the complexities of the overdose crisis as well as the treatment and prevention approaches to solving it.